Characterizing Cancer Drug Response and Biological Correlates: A Geometric Network Approach
نویسندگان
چکیده
منابع مشابه
Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities
The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to perceived obstacles of cost and analysis. One barrier to examining transcriptional dose responses is that existing methods for microarray data analysis can identify patterns, but provide no quantitative pharmacological information. We de...
متن کاملA Chance Constraint Approach to Multi Response Optimization Based on a Network Data Envelopment Analysis
In this paper, a novel approach for multi response optimization is presented. In the proposed approach, response variables in treatments combination occur with a certain probability. Moreover, we assume that each treatment has a network style. Because of the probabilistic nature of treatment combination, the proposed approach can compute the efficiency of each treatment under the desirable reli...
متن کاملCharacterizing Geometric Designs
We conjecture that the classical geometric 2-designs PGd(n, q), where 2 ≤ d ≤ n− 1, are characterized among all designs with the same parameters as those having line size q + 1. The conjecture is known to hold for the case d = n − 1 (the Dembowski-Wagner theorem) and also for d = 2 (a recent result established by Tonchev and the present author). Here we extend this result to the cases d = 3 and...
متن کاملA Meta-Analysis Approach for Characterizing Pan-Cancer Mechanisms of Drug Sensitivity in Cell Lines
Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-drug resistance (MDR) genes and mutational alterations of drug targets. However, these alterations are sufficient to explain only a minority of the po...
متن کاملCharacterizing the malignancy and drug resistance of cancer cells from their membrane resealing response
In this report, we showed that two tumor cell characteristics, namely the malignancy and drug-resistance status can be evaluated by their membrane resealing response. Specifically, membrane pores in a number of pairs of cancer and normal cell lines originated from nasopharynx, lung and intestine were introduced by nano-mechanical puncturing. Interestingly, such nanometer-sized holes in tumor ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-24679-3